Ovarian Cancer Test Kit

Ovarian cancer is the second most common gynecologic malignancy in developed countries and the third most common gynecologic malignancy in developing countries (cervical cancer is the most common) [1].Estimation of cancer antigen 125 (CA125) levels and transvaginal sonography are the best and most frequently recommended methods for diagnosing ovarian cancer [2,3,4]. HE4 and CA72-4 determination is the best approach to confirm the benign nature of ovarian endometrioma in women with high CA125 levels. [5]

Clinical Significance

when measured together with other tumoral markers (such as CA19.9 or CEA)CA125 was assessed by numerous investigators regarding its utility as a marker of stage, disease status, prognosis or even in the screening of ovarian cancer. [6]

HE4 is the most useful marker for the differ-ential diagnosis between EOC and ovarian endometriosis[7]. Different studies propose the use of a Risk of Ovarian Malignancy Algorithm (ROMA) to improve the sensitivity and specificity of the combined use of both HE4 and CA125 in patients with abdominal masses.[8]

CA 72-4 is a tumor marker for gastrointestinal cancer and ovarian cancer. Compared with CA125, the positive rate of CA72-4 is higher in mucinous ovarian cancer. The combination of the two tumor makers can improve the diagnostic sensitivity of ovarian cancer.